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Featured Testimonials
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"The result of my testing this product is exciting and positive to say the least!
I saw and felt great overall development, increased energy and an endurance boost after using Embla Arginine. My sleep pattern is wonderful and I’m very much awake in the morning. I believe that Embla Arginine is the real deal.
For over 25 years, I used and became very familiar with L-Arginine based Human Growth Hormone (HGH) secretagogue products. Based on this familiarity, I’ve been very critical of products that claim to provide HGH release. I’ve found no other product that includes the kind of catalyst that Embla Arginine’s Cardio Care and Cardio Pro provide. It sounds easy, but the carrier, or the complete L-Arginine product, is more complex than what I make it out to be in my previous statement. I’m not a chemist or pharmacist, but an experienced end-user and I’ve competed using L-Arginine, talked about it, and recommended its use over the years. Embla Arginine is a unique one because the designers focused on building a product that addresses the needs of the athlete and non-athletes alike. They successfully created a product which contains immune support for the cells, a scavenger for harmful free radicals and arterial support for circulation.!
Bill’s introduction to competitive bodybuilding was at the Mr. Worcester, MA in 1973. In 1986, Bill entered the 220 class and became the world power lifting champion for that division. He was also runner up in Mr. International and Mr. America in that same year. Bill continued to compete until 1996 winning many other class competitions and national, international and invitational titles in powerlifting. Bill was a finalist in the Mr. World event of 1991 thus ending a very successful career on the arduous competitive circuit.
Currently, Bill is a personal trainer and consultant to professional athletes, medical doctors and amateur sports participant. Bill has developed a profound proclivity toward baby-boomers. His training techniques are highly successful for athletes and non-athletes alike. Bill provides unique and systematic training regimens for his clients and utilizes his many years at the top of the competitive game as well as his never ending acquisition of knowledge to assist his clients in accomplishing their health and wellness goals"
Bill Busby
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Embla Arginine -
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Scientific Studies Regarding L-Arginine
The scientific literature (including Nobel Prize and thousands of studies and research papers) relative to the benefits of L-Arginine derived Nitric-Oxide supplementation are one of the greatest documentation collations ever created for any supplement.
Please note, however, that the following information and references to scientific studies are disavowed as product labeling or product claims, but are ancillary, educational material ONLY. Also, we affirm that the studies cited may or may not be consistent with the loftier status of representing a consensus of scientific opinion. These scientific reports do not predict what L-Arginine (or Embla Arginine oroducts) will accomplish for any particular person. They are nutrient tools. Nothing more... and each person’s body uses that tools as it chooses.
What benefits 999,999 out of one million people may be very dangerous for another individual. These studies must not be relied upon for therapeutic or other health decisions because the study summaries may omit key information or the study conclusions may be obviated by other, better designed studies, or by matters relevant to individuals with a particular type of health problem. Anyone contemplating a change in health practices should consult their physician before doing so. These studies are included ONLY for educational purposes for their value in providing starting points for one’s own research to find possible directions for one’s health.
L-Arginine Scientific Facts Summary
- Amino acids are the building blocks of protein, and protein is the building block of all living cells. The greatest portion of human body weight, after water, is protein.
- L-Arginine is a vitally important amino acid that has been studied for more than fifty years.
- The study of amino acids is making a major contribution to the understanding of disease. Amino acid therapies have been used successfully to prevent aging, prevent heart disease, enhance memory retention, eliminate depression, control stress, improve sleep, relieve arthritis, reduce herpes, arrest alcoholism, manage allergies, and much more.
- The amino acid L-Arginine has been linked to enhanced immunity, the release of the Human Growth Hormone (HGH), increased muscle mass, rapid healing from injury, increased sexual potency, increased cardiac output, helping to reverse atherosclerosis and many other benefits.
- One of the ‘interesting’ realities regarding L-Arginine supplementation has to do with the fact that one amino acid can cancel the effect of another. This is true with L-Arginine — L-Arginine has an antagonistic relationship with Lysine. On the other hand, L-Arginine has a complementary relationship with Citrulline.
- Interestingly, animals instinctively eat one food at a time, and thus can get the full benefit of L-Arginine rich foods, while humans who like to mix foods in a single meal often lose the benefit of eating L-Arginine-rich foods since they are simultaneously eating Lysine rich foods and the L-Arginine benefit is canceled by the Lysine, and vice-versa.
- L-Arginine can cross the blood brain barrier. The brain contains transport systems for amino acids. A “rider” is not necessary for L-Arginine to cross the blood-brain barrier.
- The body's ability to utilize amino acids can be adversely affected by an individual's advancing age, overall health, organ health, the presence of infection, physical trauma such as injury, effects of stress, compromised nutrient absorption capacity, and imbalance of other nutrients.
- One of the main causes of a decreasing ability to utilize amino acids is damage to endothelial cells (the more years a person has lived, the more likely endothelial cells will be damaged). A telltale sign of endothelial damage is a buildup of arterial plaque. That’s why it is important to promote the repair of endothelial cells and enhance endothelial cell functioning with botanicals such as chromium, vanadium, choline, folic acid, banaba — nutrients that are in the Embla Arginine formulation.
- L-Arginine can stimulate the hypothalamus to provoke the pituitary into releasing Human Growth Hormone.
- A 15 to 30 gram intravenous infusion of L-Arginine is a standard endocrinological test for assessing pituitary health, by measuring resultant serum HGH.
L-Arginine Scientific Study Briefs and References
L-Arginine and Increased Cardiac Output
In research conducted by Tokyo’s Keio University School of Medicine in 1992, patients were given intravenous doses of L-Arginine that produced rapid lowering in blood pressure as well as marked increases in the volume of blood the heart pumps per beat, called the cardiac output. The investigators concluded “our results provide evidence for the first time that systemically administered L-Arginine releases Nitric-Oxide in man.
Restoration of Sexual Function in Impotent Men
In a 1994 study by Drs. A.W. Zogmotti and EGA. Lizza of the department of urology / surgery at New York University School of Medicine, six of fifteen men who took 2,800 milligrams of L-Arginine a day for two weeks had renewed sexual performance, specifically improved erection, yet none of the men on the placebo did. The researchers believe that L-Arginine worked because it is a precursor of Nitric-Oxide, which plays a key role in initiating and maintaining an erection.
Reversal of Endothelial Dysfunction
At the Mayo Clinic in 1999, a six-month-long study was designed to examine whether supplements of L-Arginine could reverse endothelial dysfunction in people with coronary artery disease. Twenty-six patients participated in the study, and received either oral L-Arginine supplements (3 grams a day) or placebo. After six months, the endothelial function and blood flow throughout the coronary vessels improved in the supplement group, as did the symptoms of coronary artery disease in these patients.
Lowered Blood Pressure
In a study at Hannover Medical School in Germany, ten healthy men were given intravenous L-Arginine (a 30-gram dose) administered over thirty minutes). Patients experienced not only a decrease in their blood pressure readings, with the declines more pronounced in diastolic than systolic pressures, but there was also a 33 percent reduction in the clumping or aggregation of their blood platelets.
In research at Keio University School of Medicine in Tokyo, five patients with high blood pressure (average readings of 155/95 mm Hg) were given IV doses of L-Arginine. During administration of the amino acid, both systolic and diastolic blood pressure readings declined to an average of 125/73, respectively.
Circulation Improvement
In another study at Hannover Medical School, scientists examined the effects of L-Arginine on peripheral artery disease, which involves the narrowing of blood vessels to the leg arteries, leading to symptoms like severe pain in the calf muscles during walking (a condition called “intermittent claudication”). The investigators evaluated thirty-nine patients with intermittent claudication, giving them either two daily infusions of L-Arginine (8 grams each), prostaglandin E1 (a vasodilator), or no treatment for three weeks. Those individuals receiving L-Arginine experienced greater improvement in their pain-free walking distance and their absolute walking distance than those on prostaglandins, while there was no significant change in the control patients. L-Arginine also improved the vessel dilation in the thighs associated with endothelial function, while prostaglandin produced no such improvement. The research concluded, “Restoring Nitric-Oxide formation and endothelim-dependent vasodilation by L-Arginine improves the clinical symptoms of intermittent claudication in patients with peripheral arterial occlusive disease.
Reduction in Blood Platelet Stickiness
At Stanford University’s Division of Cardiovascular Medicine, researchers set out to determine whether L-Arginine supplementation could reduce blood platelet stickiness in individuals with high blood cholesterol levels. They placed patients on oral L-Arginine supplements (8.4 grams a day) or placebo. After two weeks, platelet aggregation was modestly reduced in the people taking L-Arginine; an effect that continued for another two weeks after the L-Arginine supplementation had been stopped. The platelet activity returned to baseline levels eighteen weeks after the last supplements were taken. No side effects associated with L-Arginine were reported. The researchers noted that these findings were similar to those in previous animal studies, which found that L-Arginine restored Nitric-Oxide activity while interfering with platelet aggregation.
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http://www.youtube.com/watch?v=YPHMFfiVCYA
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Research Articles
L-Arginine increases methylation, Leptin sensitivity and leanness in laboratory animals - http://circres.ahajournals.org/cgi/content/abstract/107/8/992
Restoring Leptin sensitivity cures severe diabetes and doubles activity levels in mice - http://www.thaindian.com/newsportal/health/restoring-Leptin-sensitivity-in-brain-cures-severe-diabetes-doubles-activity-levels-in-mice_100200112.html
L-Arginine supplementation improves endothelial and insulin receptivity - http://ajpendo.physiology.org/content/291/5/E906.full
Nitric-Oxide encourages fat metabolism in the mitochondria - http://endo.endojournals.org/cgi/content/full/148/10/4545
Hambrecht R, Hilbrich L, Erbs S, et al. Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-Arginine supplementation. J Am Coll Cardiol. 2000;35:706-713.
Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-Arginine in patients with heart failure. Circulation. 1996;93:2135-2141.
Watanabe G, Tomiyama H, Doba N. Effects of oral administration of L-Arginine on renal function in patients with heart failure. J Hypertens. 2000;18:229-234.
Chen J, Wollman Y, Chernichovsky T, et al. Effect of oral administration of high-dose nitric oxide donor L-Arginine in men with organic erectile dysfunction: results of a double-blind, randomized placebo-controlled study. BJU Int. 1999;83:269-273.
Maxwell A. Annual meeting of American College of Cardiology; 1999.
Boger RH, Bode-Boger SM, Thiele W, et al. Restoring vascular nitric oxide formation by L-Arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. J Am Coll Cardiol. 1998;32:1336-1344.
Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-Arginine for treatment of interstitial cystitis. J Urol. 1999;161:558-565.
Meston CM, Worcel M. The effects of yohimbine plus L-Arginine glutamate on sexual arousal in postmenopausal women with sexual arousal disorder. Arch Sex Behav. 2002;31:323-332.
Bednarz B, Wolk R, Chamiec T, et al. Effects of oral L-Arginine supplementation on exercise-induced QT dispersion and exercise tolerance in stable angina pectoris. Int J Cardiol. 2000;75:205-210.
Baligan M, Giardina A, Giovannini G, et al. L-Arginine and immunity. Study of pediatric subjects [translated from Italian]. Minerva Pediatr. 1997;49:537-542.
De Aloysio D, Mantuano R, Mauloni M, et al. The clinical use of L-Arginine aspartate in male infertility. Acta Eur Fertil. 1982;13:133-167.
Tanimura J. Studies on L-Arginine in human semen. II. The effects of medication with L-Arginine-HCl on male infertility. Bull Osaka Med Sch. 1967;13:84-89.
Schachter A, Goldman JA, Zukerman Z. Treatment of oligospermia with the amino acid L-Arginine. J Urol. 1973;110:311-313.
Schachter A, Friedman S, Goldman JA, et al. Treatment of oligospermia with the amino acid L-Arginine. Int J Gynaecol Obstet. 1973;11:206-209.
Mroueh A. Effect of L-Arginine on oligospermia. Fertil Steril. 1970;21:217-219.
Pryor JP, Blandy JP, Evans P, et al. Controlled clinical trial of L-Arginine for infertile men with oligozoospermia. Brit J Urol. 1978;50:47-50.
Battaglia C, Salvatori M, Maxia N, et al. Adjuvant L-Arginine treatment for in-vitro fertilization in poor responder patients. Hum Reprod. 1999;14:1690-1697.
Piatti PM, Monti LD, Valsecchi G, et al. Long-term oral L-Arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients. Diabetes Care. 2001;24:875-880.
De Nicola L, Bellizzi V, Minutolo R, et al. Randomized, double-blind, placebo controlled study of L-Arginine supplementation in chronic renal failure. Kidney Int. 1999;56:674-684.
Beale R, Bryg D, Bihari D. Immunonutrition in the critically ill: A systematic review of clinical outcome. Crit Care Med. 1999;27:2799-2805.
Hambrecht R, Hilbrich, L, Erbs S, et al. Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-Arginine supplementation. J Am Coll Cardiol. 2000;35:706-713.
Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-Arginine in patients with heart failure. Circulation. 1996;93:2135-2141.
Watanabe G, Tomiyama H, Doba N. Effects of oral administration of L-Arginine on renal function in patients with heart failure. J Hypertens. 2000;18:229-234.
Maxwell A. Annual meeting of American College of Cardiology; 1999.
Boger RH, Bode-Boger SM, Thiele W, et al. Restoring vascular nitric oxide formation by L-Arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. J Am Coll Cardiol. 1998;32:1336-1344.
Bednarz B, Wolk R, Chamiec T, et al. Effects of oral L-Arginine supplementation on exercise-induced QT dispersion and exercise tolerance in stable angina pectoris. Int J Cardiol. 2000;75:205-210.
Chen J, Wollman Y, Chernichovsky T, et al. Effect of oral administration of high-dose nitric oxide donor L-Arginine in men with organic erectile dysfunction: results of a double-blind, randomized placebo-controlled study. BJU Int. 1999;83:269-273.
Meston CM, Worcel M. The effects of yohimbine plus L-Arginine glutamate on sexual arousal in postmenopausal women with sexual arousal disorder. Arch Sex Behav. 2002;31:323-332.
Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-Arginine for treatment of interstitial cystitis. J Urol. 1999;161:558-565.
Cartledge JJ, Davies A, Eardley I. A randomized double-blind placebo-controlled crossover trial of the efficacy of L-Arginine in the treatment of interstitial cystitis. BJU Int. 2000;85:421-426.
Baligan M, Giardina A, Giovannini G, et al. L-Arginine and immunity. Study of pediatric subjects [translated from Italian]. Minerva Pediatr. 1997;49:537-542.
Beale R, Bryg D, Bihari D. Immunonutrition in the critically ill: A systematic review of clinical outcome. Crit Care Med. 1999;27:2799-2805.
Piatti PM, Monti LD, Valsecchi G, et al. Long-term oral L-Arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients. Diabetes Care. 2001;24:875-880.
AHFS Drug Information. Bethesda, MD: American Society of Hospital Pharmacists. 2000:2306-2307.
AHFS Drug Information. Bethesda, MD: American Society of Hospital Pharmacists. 2000:2306-2307.
Piatti PM, Monti LD, Valsecchi G, et al. Long-term oral L-Arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients. Diabetes Care. 2001;24:875-880.
Bruinsma KA, Anderson BE, Prendergast JJ, et al. Effects of an L-Arginine-enriched medical food in patients with type II diabetes [abstract]. Diabetes. 2001;50(suppl 2):1796-PO.
Griffith RS, DeLong DC, Nelson J. Relation of L-Arginine-lysine antagonism to herpes simplex growth in tissue culture. Chemotherapy. 1981;27:209-213.
Klotz T, Mathers MJ, Braun M, et al. Effectiveness of oral L-Arginine in first-line treatment of erectile dysfunction in a controlled crossover study. Urol Int. 1999;63:220-223.
Maxwell AJ, Zapien MP, Pearce GL, et al. Randomized trial of a medical food for the dietary management of chronic, stable angina. J Am Coll Cardiol. 2002;39:37-45.
Luiking YC, Weusten BL, Portincasa P, et al. Effects of long-term oral L-Arginine on esophageal motility and gallbladder dynamics in healthy humans. Am J Physiol. 1998;274(6 pt 1):G984-G991.
Khan F, Litchfield SJ, McLaren M, et al. Oral L-Arginine supplementation and cutaneous vascular responses in patients with primary Raynaud's phenomenon. Arthritis Rheum. 1997;40:352-357.
Maxwell AJ, Anderson BE, Cooke JP. Nutritional therapy for peripheral arterial disease: a double-blind, placebo-controlled, randomized trial of HeartBar. Vasc Med. 2000;5:11-19.
Parker JO, Parker JD, Caldwell RW, et al. The effect of supplemental L-Arginine on tolerance development during continuous transdermal nitroglycerin therapy. J Am Coll Cardiol. 2002;39:1199-1203.
de Gouw HW, Verbruggen MB, Twiss IM, et al. Effect of oral L-Arginine on airway hyperresponsiveness to histamine in asthma. Thorax. 1999;54:1033-1035.
Pryor JP, Blandy JP, Evans P, et al. Controlled clinical trial of L-Arginine for infertile men with oligozoospermia. Br J Urol. 1978;50:47-50.
Lebret T, Herve JM, Gorny P, et al. Efficacy and safety of a novel combination of L-Arginine glutamate and yohimbine hydrochloride: a new oral therapy for erectile dysfunction. Eur Urol. 2002;41:608-613.
Abdelhamed AI, Reis SE, Sane DC, et al. No effect of an L-Arginine-enriched medical food (HeartBars) on endothelial function and platelet aggregation in subjects with hypercholesterolemia. Am Heart J. 2003.;145:E15.
Ito TY, Trant AS, Polan ML. A double-blind placebo-controlled study of ArginMax, a nutritional supplement for enhancement of female sexual function. J Sex Marital Ther. 2001;27:541-549.
Morris CR, Morris Jr. SM, Hagar W, et al. L-Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease? Am J Respir Crit Care Med. 2003;168:63-69.
Staff AC, Berge L, Haugen G, et al. Dietary supplementation with L-Arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand. 2004;83:103-107.
Rytlewski K, Olszanecki R, Korbut R, et al. Effects of prolonged oral supplementation with L-Arginine on blood pressure and nitric oxide synthesis in preeclampsia. Eur J Clin Invest. 2005;35:32-37.
Grasemann H, Grasemann C, Kurtz F, et al. Oral L-Arginine supplementation in cystic fibrosis patients: a placebo-controlled study. Eur Respir J. 2005;25:62-68.
Stanislavov R, Nikolova V. Treatment of erectile dysfunction with pycnogenol and L-Arginine. J Sex Marital Ther. 2003;29:207-213.
Bednarz B, Jaxa-Chamiec T, Maciejewski P, et al. Efficacy and safety of oral L-Arginine in acute myocardial infarction. Results of multicenter, randomized, double-blind, placebo-controlled ARAMI pilot trial. Kardiol Pol. 2005;62:421-427.
Schulman SP, Becker LC, Kass DA, et al. L-Arginine therapy in acute myocardial infarction. The Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial. JAMA. 2006;295:58-64.
Moriguti JC, Ferriolli E, Donadi EA, et al. Effects of L-Arginine supplementation on the humoral and innate immune response of older people. Eur J Clin Nutr. 2005 Jul 27. [Epub ahead of print]
Rytlewski K, Olszanecki R, Korbut R, et al. Effects of prolonged oral supplementation with L-Arginine on blood pressure and nitric oxide synthesis in preeclampsia. Eur J Clin Invest. 2005;35:32-37.
Baecker N, Boese A, Schoenau E, et al. L-Arginine, the Natural Precursor of NO, Is Not Effective for Preventing Bone Loss in Postmenopausal Women. J Bone Miner Res. 2005;20:471-479.
Mansoor JK, Morrissey BM, Walby WF, et al. L-Arginine Supplementation Enhances Exhaled NO, Breath Condensate VEGF, and Headache at 4342 m. High Alt Med Biol. 2005;6:289-300.
Ito T, Kawahara K, Das A. A double-blind placebo-controlled study on the effects of ArginMax, a natural nutritional supplement for enhancement of male sexual function. Arginmax website.Available at: http://www.arginmax.com/html/abstract.htm. Accessed October 15, 2005.
Ito TY, Polan ML, Whipple B, et al. The enhancement of female sexual function with ArginMax, a nutritional supplement, among women differing in menopausal status. J Sex Marital Ther. 2006;32:369-378
Wilson AM, Harada R, Nair N, et al. L-Arginine supplementation in peripheral arterial disease. No benefit and possible harm. Circulation. 2007 Jun 25. [Epub ahead of print]
Maxwell AJ, Anderson BE, Cooke JP. Nutritional therapy for peripheral arterial disease: a double-blind, placebo-controlled, randomized trial of HeartBar. Vasc Med. 2000;5:11-19.
Shao A, Hathcock JN. Risk assessment for the amino acids taurine, l-glutamine and L-Arginine. Regul Toxicol Pharmacol. 2008 Jan 26.
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